Loss of nuclear localization of TET2 in colorectal cancer

11Citations
Citations of this article
32Readers
Mendeley users who have this article in their library.

Abstract

5-Hydroxymethylcytosine (5hmC) is lost in multiple human cancers, including colorectal cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but not other two TET family members, has been observed in the colorectal cancer and is crucial for colorectal cancer initiation. Here, we show that nuclear localization of TET2 was lost in a significant portion of CRC tissues, in association with metastasis. In CRC cells, nuclear expression of TET2 were absent but not TET3. Nuclear export inhibitor can increase the 5hmC level in CRC cells, probably through regulating TET2. Our results indicate a new mechanism of TET2 dysregulation in colorectal cancer.

Cite

CITATION STYLE

APA

Huang, Y., Wang, G., Liang, Z., Yang, Y., Cui, L., & Liu, C. Y. (2016, January 26). Loss of nuclear localization of TET2 in colorectal cancer. Clinical Epigenetics. Springer Verlag. https://doi.org/10.1186/s13148-016-0176-7

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free