M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes

16Citations
Citations of this article
17Readers
Mendeley users who have this article in their library.

Abstract

Invasive infections caused by the important pathogen Streptococcus pyogenes are often associated with disturbed blood coagulation in the human host, and may in severe cases develop into the life-threatening condition disseminated intravascular coagulation. In this study, the addition of M1 protein to human blood or purified peripheral blood mononuclear cells led to a dose-dependent increase of pro-coagulant activity, which was mediated by an upregulation of tissue factor on monocytes. Analysis of the resulting clots by transmission electron microscopy revealed that the cells were covered with a fibrin network that seemed to originate from the cell surface. Taken together, the results imply an important role for M proteins in the induction of haemostatic disorders in invasive streptococcal infectious diseases. © 2007 SGM.

Cite

CITATION STYLE

APA

Påhlman, L. I., Malmström, E., Mörgelin, M., & Herwald, H. (2007). M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes. Microbiology, 153(8), 2458–2464. https://doi.org/10.1099/mic.0.2006/003285-0

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free