Graphical Abstract Highlights d Peripherally derived macrophages (BMDMs) and microglia (MG) infiltrate brain tumors d BMDMs and MG possess distinct transcriptional profiles and activation states in cancer d Chromatin landscapes are distinct between BMDMs and MG d CD49D is absent on MG and distinguishes them from BMDMs in mouse and human tumors In Brief Bowman et al. use genetic lineage tracing models to interrogate the ontogeny of tumor-associated macrophages in brain malignancy. These studies show that bone-marrow-derived macrophages (BMDMs) and tissue-resident microglia (MG) are present in glioma and brain metastases, possessing distinct transcriptional and chromatin states, and identify markers distinguishing these cell populations.
Pyonteck, S. M., Gardner, E. E., Gutin, P. H., Akkari, L., Joyce, J. A., Quail, D. F., … Sevenich, L. (2016). Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies. Cell Reports, 17(9), 2445–2459. https://doi.org/10.1016/j.celrep.2016.10.052