Mass spectrometry has been the focus of technology development and application for imaging for several decades. Imaging mass spectrometry using matrix-assisted laser desorption ionization is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.
Manzanares-Meza, L. D., Gutiérrez-Román, C. I., & Medina-Contreras, O. (2017, May 1). MALDI imaging: beyond classic diagnosis. Boletin Medico Del Hospital Infantil de Mexico. Masson-Doyma Mexico, S.A. https://doi.org/10.1016/j.bmhimx.2017.03.004