The mammalian Nek1 kinase is involved in primary cilium formation

51Citations
Citations of this article
77Readers
Mendeley users who have this article in their library.

Abstract

Recent studies implicate primary cilium (PC) proteins in the etiologies of various polycystic kidney diseases (PKD). NIMA-related kinases (NRKs) are conserved serine/threonine kinases, which are usually defined as 'mitotic kinases'. Murine mutants for the NRKs, nek1 (kat mice) suffer from PKD, suggesting that it may be involved in cilium control. We demonstrated herein that Nek1 is localized to basal body region and that Nek1 overexpression inhibits ciliogenesis in Madin-Darby canine kidney epithelial cells. The number of primary cilia is dramatically reduced in kat2J mouse embryonic fibroblasts culture. It is thus hypothesized that Nek1 links cell cycle progression and the PC cycle. © 2008 Federation of European Biochemical Societies.

Cite

CITATION STYLE

APA

Shalom, O., Shalva, N., Altschuler, Y., & Motro, B. (2008). The mammalian Nek1 kinase is involved in primary cilium formation. FEBS Letters, 582(10), 1465–1470. https://doi.org/10.1016/j.febslet.2008.03.036

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free