Map of chartreusin and elsamicin binding sites on DNA

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Three DNA restriction fragments designated tyrT, 102-mer and 70-mer, have been used as substrates for footprinting studies using DNase I in the presence of the structurally similar antibiotics chartreusin and elsamicin A, The sequence-selective binding sites of the antibiotics can be mapped in regions which are rich In guanine+cytosine. Chartreusin and elsamicin appear to recognize and bind preferentially to sequences containing a CpG step. Regions containing a TpG step also seem to be a good binding site. The binding of elsamicin to these sites appears to be more concentration-dependent. A comparative analysis is performed of the sizes and locations of the different binding sites, aimed to infer whether the different biological effects of chartreusin and elsamicin A can be correlated to differences in their sequence-selective binding to DNA. © 1991.




Salas, X., & Portugal, J. (1991). Map of chartreusin and elsamicin binding sites on DNA. FEBS Letters, 292(1–2), 223–228.

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