MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation

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Abstract

That signalling pathways, particularly the mitogen-activated protein kinase cascades, elicit modification of chromatin proteins such as histone H3 by phosphorylation and/or acetylation concomitant with gene activation is now well established. The picture that is emerging is one of a complex and dynamic pattern of multiple modifications at the H3 tail. Here, we review the inducible gene systems where H3 modifications have been reported and re-evaluate the controversy as to the kinase(s) that phosphorylates it as well as the proposed coupling between H3 phosphorylation and acetylation. © 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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Clayton, A. L., & Mahadevan, L. C. (2003, July 3). MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation. FEBS Letters. Elsevier. https://doi.org/10.1016/S0014-5793(03)00451-4

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