Marked enhancement in myocardial function resulting from overexpression of a human β-adrenergic receptor gene

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Abstract

Transgenic mice with intense cardiac expression of human β-adrenergic receptor gene were engineered and shown to display market improvements in baseline myocardial and left ventricular function. Heart/body weight ratios and histologic appearance were not found to be significantly altered, suggesting that receptor gene expression did not induce pathologic changes. Given the substantial reduction in β-adrenergic receptor density and result reduction in inotropic responsiveness observed in chronic heart failure, these finding represent a novel approach for increasing myocardial function with important clinical implications. (J THORAC CARDIOVASC SURG 1995;109:236-41). © 1995 Mosby, Inc. All rights reserved.

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Milano, C. A., Allen, L. F., Dolber, P. C., Johnson, T. D., Rockman, H. A., Bond, R. A., & Lefkowitz, R. J. (1995). Marked enhancement in myocardial function resulting from overexpression of a human β-adrenergic receptor gene. The Journal of Thoracic and Cardiovascular Surgery, 109(2), 236–241. https://doi.org/10.1016/S0022-5223(95)70384-5

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