Matrix Mg2+ regulates mitochondrial ATP-dependent potassium channel from heart

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Abstract

Mitochondrial ATP-regulated potassium (mitoKATP) channels play an important role in cardioprotection. Single channel activity was measured after reconstitution of inner mitochondrial membranes from bovine myocardium into a planar lipid bilayer. After incorporation, the potassium channel was recorded with a mean conductance of 103 ± 9 pS. The channel activity was inhibited by ATP/Mg and activated by GDP. Magnesium ions alone affected, in a dose dependent manner, both the channel conductance and the open probability. Magnesium ions regulated the mitoKATP channel only when added to the trans compartment. We conclude that Mg2+ regulates the cardiac mitoKATP channel from the matrix site by affecting both the channel conductance and gating. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Bednarczyk, P., Dołowy, K., & Szewczyk, A. (2005). Matrix Mg2+ regulates mitochondrial ATP-dependent potassium channel from heart. FEBS Letters, 579(7), 1625–1632. https://doi.org/10.1016/j.febslet.2005.01.077

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