MB-SWIFT functional MRI during deep brain stimulation in rats

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Abstract

Recently introduced 3D radial MRI pulse sequence entitled Multi-Band SWeep Imaging with Fourier Transformation (MB-SWIFT) having virtually zero acquisition delay was used to obtain functional MRI (fMRI) contrast in rat's brain at 9.4 T during deep brain stimulation (DBS). The results demonstrate that MB-SWIFT allows functional images free of susceptibility artifacts, and provides an excellent fMRI activation contrast in the brain. Flip angle dependence of the MB-SWIFT fMRI signal and elimination of the fMRI contrast while using saturation bands, indicate a blood flow origin of the observed fMRI contrast. MB-SWIFT fMRI modality permits activation studies in the close proximity to an implanted lead, which is not possible to achieve with conventionally used gradient echo and spin echo - echo planar imaging fMRI techniques. We conclude that MB-SWIFT fMRI is a powerful imaging modality for investigations of functional responses during DBS.

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Lehto, L. J., Idiyatullin, D., Zhang, J., Utecht, L., Adriany, G., Garwood, M., … Mangia, S. (2017). MB-SWIFT functional MRI during deep brain stimulation in rats. NeuroImage, 159, 443–448. https://doi.org/10.1016/j.neuroimage.2017.08.012

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