Abstract

Background: The live measles vaccine has been associated with lower non-measles mortality and admissions in low-income countries. The live measles-mumps-rubella vaccine has also been associated with lower rate of admissions with any type of infection in Danish children; the association was strongest for admissions with lower respiratory infections. Objective: To examine whether measles, mumps, and rubella (MMR) vaccination was associated with reduced rate of hospital contact related to respiratory syncytial virus (RSV) in a high-income country. Methods: Nationwide cohort study of laboratory-confirmed RSV hospital contacts at age 14-23 months in all children born in Denmark 1997-2002 who had already received the vaccine against diphtheria, tetanus, pertussis (acellular), polio, and Haemophilus influenzae type b (DTaP-IPV-Hib) at the recommended ages of 3, 5, and 12 months. Results: The study included 888 RSV hospital contacts in 128,588 person years of follow up (rate 6.8/1000 person years). Having MMR as the most recent vaccine was associated with a reduced rate of RSV hospital contacts compared with having DTaP-IPV-Hib as the most recent vaccine (Incidence rate ratio (IRR), 0.75; 95% confidence interval (CI), 0.63-0.89). After adjustment for potential confounders including exact age in days the IRR was 0.78 (95% CI, 0.66-0.93). The adjusted IRR was 0.74 (95% CI, 0.60-0.92) in males and 0.84 (95% CI, 0.66-1.06) in females (. P Interaction, 0.42). There was no association in the first month after MMR vaccination (adjusted IRR, 0.97; 95% CI, 0.76-1.24) but the adjusted IRR was 0.70 (95% CI, 0.58-0.85) from one month after MMR vaccination. Conclusions: MMR vaccination was associated with reduced rate of hospital contacts related to laboratory-confirmed RSV infection. Further research on the association between MMR vaccination and other unrelated pathogens are warranted.

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CITATION STYLE

APA

S., S., C.S., B., L.G., S., P., A., & H., R. (2015). Measles-mumps-rubella vaccination and respiratory syncytial virus-associated hospital contact. Vaccine, 33(1), 237–245. https://doi.org/10.1016/j.vaccine.2014.07.110 LK  - http://resolver.ebscohost.com/openurl?sid=EMBASE&issn=18732518&id=doi:10.1016%2Fj.vaccine.2014.07.110&atitle=Measles-mumps-rubella+vaccination+and+respiratory+syncytial+virus-associated+hospital+contact&stitle=Vaccine&title=Vaccine&volume=33&issue=1&spage=237&epage=245&aulast=S%C3%B8rup&aufirst=Signe&auinit=S.&aufull=S%C3%B8rup+S.&coden=VACCD&isbn=&pages=237-245&date=2015&auinit1=S&auinitm=

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