The Mechanism of the Inhibition of Gastric Secretion Produced by Esophageal Ligation in the Pylorus-Ligated Rat

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Abstract

Esophageal ligation in the, pylorusligated rat significantly inhibited volume, titratable acidity, and titratable acid output and reduced the incidence of ulcers, perforations, and death of 18-hr pylorusligated rats. Draining the saliva outside the body of the rat by esophageal cannulation produced a significant increase in volume and gastric acidity over the esophagusligated preparation. A method for collection of saliva in the unanesthetized unstimulated rat was developed, and basal salivary flow was found to be 0.84 ml/4 hr. Administration of 1.0 ml of freshly collected saliva to esophagus + pylorus-ligated rats increased titratable acidity, but not volume of secretion, to the level found in the pylorus-ligated rat. A similar effect was obtained with administration of 1.0 ml of a phosphate buffer. Removal of the salivary glands had no significant effect on gastric acidity in the pylorus-ligated rat and the reduction in volume could be accounted for by the lack of saliva. Gastric secretion in the esophagus + pylorus-ligated rat was stimulated by histamine, carbachol, insulin, and 2-deoxyglucose. When the vagus nerves were cut, stimulation was still obtained with carbachol but not with insulin or 2-deoxyglucose. The data indicated that (1) rat saliva did not contain a specific gastric stimulant material, and (2) esophageal ligation depressed gastric secretion in the pylorusligated rat by inhibition of the central vagal activity. © 1966, The Williams & Wilkins Company. All rights reserved.

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Brodie, D. A., & Knapp, P. G. (1966). The Mechanism of the Inhibition of Gastric Secretion Produced by Esophageal Ligation in the Pylorus-Ligated Rat. Gastroenterology, 50(6), 787–795. https://doi.org/10.1016/S0016-5085(66)80008-2

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