Melanoma Suppressor Functions of the Carcinoma Oncogene FOXQ1

3Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

Abstract

Lineage-specific regulation of tumor progression by the same transcription factor is understudied. We find that levels of the FOXQ1 transcription factor, an oncogene in carcinomas, are decreased during melanoma progression. Moreover, in contrast to carcinomas, FOXQ1 suppresses epithelial-to-mesenchymal transition, invasion, and metastasis in melanoma cells. We find that these lineage-specific functions of FOXQ1 largely depend on its ability to activate (in carcinomas) or repress (in melanoma) transcription of the N-cadherin gene (CDH2). We demonstrate that FOXQ1 interacts with nuclear β-catenin and TLE proteins, and the β-catenin/TLE ratio, which is higher in carcinoma than melanoma cells, determines the effect of FOXQ1 on CDH2 transcription. Accordingly, other FOXQ1-dependent phenotypes can be manipulated by altering nuclear β-catenin or TLE proteins levels. Our data identify FOXQ1 as a melanoma suppressor and establish a mechanism underlying its inverse lineage-specific transcriptional regulation of transformed phenotypes.

Cite

CITATION STYLE

APA

Bagati, A., Bianchi-Smiraglia, A., Moparthy, S., Kolesnikova, K., Fink, E. E., Lipchick, B. C., … Nikiforov, M. A. (2017). Melanoma Suppressor Functions of the Carcinoma Oncogene FOXQ1. Cell Reports, 20(12), 2820–2832. https://doi.org/10.1016/j.celrep.2017.08.057

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free