Mesenchymal stem cell therapy for doxorubicin cardiomyopathy: Hopes and fears

11Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.

Abstract

© 2015 Ezquer et al. Chemotherapy has made an essential contribution to cancer treatment in recent decades despite its adverse effects. As cancer survivors have increased, concern about ex-patient lifespan has become more important too. Doxorubicin is an effective anti-neoplastic drug that produces a cardiotoxic effect. Cancer survivors who received doxorubicin became more vulnerable to cardiac disease than the normal population did. Many efforts have been made to prevent cardiac toxicity in patients with cancer. However, current therapies cannot guarantee permanent cardiac protection. One of their main limitations is that they do not promote myocardium regeneration. In this review, we summarize and discuss the promising use of mesenchymal stem cells for cardio-protection or cardio-regeneration therapies and consider their regenerative potential without leaving aside their controversial effects on tumor progression.

Cite

CITATION STYLE

APA

Ezquer, F., Gutiérrez, J., Ezquer, M., Caglevic, C., Salgado, H. C., & Calligaris, S. D. (2015, June 24). Mesenchymal stem cell therapy for doxorubicin cardiomyopathy: Hopes and fears. Stem Cell Research and Therapy. BioMed Central Ltd. https://doi.org/10.1186/s13287-015-0109-y

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free