Metabolic flux and the regulation of mammalian cell growth

193Citations
Citations of this article
381Readers
Mendeley users who have this article in their library.

Abstract

The study of normal mammalian cell growth and the defects that contribute to disease pathogenesis links metabolism to cell growth. Here, we visit several aspects of growth-promoting metabolism, emphasizing recent advances in our understanding of how alterations in glucose metabolism affect cytosolic and mitochondrial redox potential and ATP generation. These alterations drive cell proliferation not only through supporting biosynthesis, energy metabolism, and maintaining redox potential but also through initiating signaling mechanisms that are still poorly characterized. The evolutionary basis of these additional layers of growth control is also discussed. © 2011 Elsevier Inc.

Cite

CITATION STYLE

APA

Locasale, J. W., & Cantley, L. C. (2011, October 5). Metabolic flux and the regulation of mammalian cell growth. Cell Metabolism. https://doi.org/10.1016/j.cmet.2011.07.014

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free