In this issue of Cancer Cell, Sonoshita et al. report that Aes/Grg5 prevents metastasis of colorectal cancer cells by sequestering and inactivating Notch transcriptional effectors in distinct nuclear foci. Loss of Aes/Grg5 in invasive cancer cells where Notch is activated by stroma-expressed ligands promotes invasion, transendothelial migration, intravasation, and metastasis. © 2011 Elsevier Inc.
Christofori, G. (2011, January 18). Metastatic colon cancer cells negotiate the intravasation notch. Cancer Cell. https://doi.org/10.1016/j.ccr.2011.01.003