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Metastatic colon cancer cells negotiate the intravasation notch

Cancer Cell
DOI: 10.1016/j.ccr.2011.01.003
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Abstract

In this issue of Cancer Cell, Sonoshita et al. report that Aes/Grg5 prevents metastasis of colorectal cancer cells by sequestering and inactivating Notch transcriptional effectors in distinct nuclear foci. Loss of Aes/Grg5 in invasive cancer cells where Notch is activated by stroma-expressed ligands promotes invasion, transendothelial migration, intravasation, and metastasis. © 2011 Elsevier Inc.

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Christofori, G. (2011, January 18). Metastatic colon cancer cells negotiate the intravasation notch. Cancer Cell. Cell Press. https://doi.org/10.1016/j.ccr.2011.01.003

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