Chen et al. identify the H3K36me2 methyltransferase Nsd2 as a critical regulator of germinal center B (GCB) cell-follicular dendritic cell adhesion. Nsd2 directly regulates expression of multiple actin polymerization-related genes in GCB cells. Loss of Nsd2 leads to reduced GCB BCR signal, antigen acquisition, and affinity maturation.
Chen, J., Li, N., Yin, Y., Zheng, N., Min, M., Lin, B., … Wang, X. (2018). Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells. Cell Reports, 25(12), 3393-3404.e6. https://doi.org/10.1016/j.celrep.2018.11.096