Microenvironment drug resistance in multiple myeloma: emerging new players

  • Di Marzo L
  • Desantis V
  • Solimando A
  • et al.
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Abstract

Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful interplay between bone marrow stromal cells and MM cells that allows the latter to escape anti-myeloma therapies. Here we present an overview of the role of the bone marrow microenvironment in both soluble factorsmediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAMDR), focusing on the role of new players, namely miRNAs, exosomes and cancerassociated fibroblasts.

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Di Marzo, L., Desantis, V., Solimando, A. G., Ruggieri, S., Annese, T., Nico, B., … Frassanito, M. A. (2016). Microenvironment drug resistance in multiple myeloma: emerging new players. Oncotarget, 7(37). https://doi.org/10.18632/oncotarget.10849

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