Citations of this article
Mendeley users who have this article in their library.
Get full text


Neuronal communication underlies all brain activity and the genesis of complex behavior. Emerging research has revealed an unexpected role for immune molecules in the development and plasticity of neuronal synapses. Moreover microglia, the resident immune cells of the brain, express and secrete immune-related signaling molecules that alter synaptic transmission and plasticity in the absence of inflammation. When inflammation does occur, microglia modify synaptic connections and synaptic plasticity required for learning and memory. Here we review recent findings demonstrating how the dynamic interactions between neurons and microglia shape the circuitry of the nervous system in the healthy brain and how altered neuron-microglia signaling could contribute to disease.




Wu, Y., Dissing-Olesen, L., MacVicar, B. A., & Stevens, B. (2015, October 1). Microglia: Dynamic Mediators of Synapse Development and Plasticity. Trends in Immunology. Elsevier Ltd. https://doi.org/10.1016/j.it.2015.08.008

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free