Micron-sized and submicron-sized aerosol deposition in a new ex vivo preclinical model

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Abstract

? 2016 The Author(s).Background: The knowledge of where particles deposit in the respiratory tract is crucial for understanding the health effects associated with inhaled drug particles. Method: An ex vivo study was conducted to assess regional deposition patterns (thoracic vs. extrathoracic) of radioactive polydisperse aerosols with different size ranges [0.15 ?m-0.5 ?m], [0.25 ?m-1 ?m] and [1 ?m-9 ?m]. SPECT/CT analyses were performed complementary in order to assess more precisely the regional deposition of aerosols within the pulmonary tract. Experiments were set using an original respiratory tract model composed of a human plastinated head connected to an ex vivo porcine pulmonary tract. The model was ventilated by passive expansion, simulating pleural depressions. Aerosol was administered during nasal breathing. Results: Planar scintigraphies allowed to calculate the deposited aerosol fractions for particles in the three size ranges from sub-micron to micron The deposited fractions obtained, for thoracic vs. extra-thoracic regions respectively, were 89 ? 4 % vs. 11 ? 4 % for [0.15 ?m-0.5 ?m], 78 ? 5 % vs. 22 ? 5 % for [0.25 ?m-1 ?m] and 35 ? 11 % vs.65 ? 11 % for [1 ?m-9 ?m]. Conclusion: Results obtained with this new ex vivo respiratory tract model are in good agreement with the in vivo data obtained in studies with baboons and humans.

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Perinel, S., Leclerc, L., Prévôt, N., Deville, A., Cottier, M., Durand, M., … Pourchez, J. (2016). Micron-sized and submicron-sized aerosol deposition in a new ex vivo preclinical model. Respiratory Research, 17(1). https://doi.org/10.1186/s12931-016-0395-7

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