MicroRNA 486-3P as a stability marker in acute coronary syndrome

  • Wei T
  • Folkersen L
  • Ehrenborg E
  • et al.
Citations of this article
Mendeley users who have this article in their library.


Easily accessible biomarkers are needed to diagnose cardiovascular disease precisely-particularly, to distinguish between disease subtypes that are encountered in clinical practice. Per the hypothesis that plasma miRNA is valuable for this purpose, we performed complete transcriptional profiling of an miRNA discovery-set in 14 samples: three patients with ST-elevanted acute myocardial infarction (STEMI) at baseline and after three months of follow-up, four with stable ischemic heart disease (stable-IHD), and four healthy age-matched volunteers. Our aim was to determine whether we could distinguish patients with unstable plaques from stable patients following a STEMI event. After analyzing miRNA profiles, we conducted a validation study comparing three-month STEMI (n = 40) with stable-IHD (n = 35), which confirmed that mir-486-3P differentiates patients with 3-month STEMI from those with stable IHD (P=0.019).




Wei, T., Folkersen, L., Ehrenborg, E., & Gabrielsen, A. (2016). MicroRNA 486-3P as a stability marker in acute coronary syndrome. Bioscience Reports, 36(3), e00351–e00351. https://doi.org/10.1042/bsr20160023

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free