MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals

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Abstract

MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.

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Houzet, L., Yeung, M. L., de Lame, V., Desai, D., Smith, S. M., & Jeang, K. T. (2008). MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals. Retrovirology, 5. https://doi.org/10.1186/1742-4690-5-118

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