Microsome-mediated transformation of O-methylandrocymbine to demecolcine and colchicine

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Abstract

Microsomal preparations from immature seeds of Colchicum autumnale L. catalyse the ring expansion reaction of O-methylandrocymbine to demecolcine in the presence of NADPH and O2. In addition evidence is given for further transformation of demecolcine to colchicine in the presence of acetyl-CoA and NADPH. Copyright (C) 1998 Federation of European Biochemical Societies.

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Rueffer, M., & Zenk, M. H. (1998). Microsome-mediated transformation of O-methylandrocymbine to demecolcine and colchicine. FEBS Letters, 438(1–2), 111–113. https://doi.org/10.1016/S0014-5793(98)01282-4

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