Tumor angiogenesis is essential in delivering oxygen and nutrients to growing tumors, and therefore considered as a hallmark of cancer. MicroRNAs (miRNAs) have been shown to play important roles in regulating tumor angiogenesis. MicroRNA-93- 5p (miR-93-5p) has been identified as an oncogenic miRNA in a variety of human malignancies and involved in tumor angiogenesis in astrocytoma. However, the direct effect(s) of miR-93-5p on the biological behaviors of endothelial cells have not been investigated. Thus, in the present study we investigated the role(s) of miR-93-5p in regulating the functions of human umbilical vein endothelial cells (HUVECs). We found that triple negative breast cancer (TNBC) tissues with higher levels of miR-93-5p showed higher blood vessel density. Overexpression of miR-93-5p accelerated HUVECs proliferation and migration and promoted HUVECs lumen formation and sprouting in vitro, while blockade of miR-93-5p suppressed HUVECs migration and angiogenic capacity. The mechanistic studies revealed that miR-93-5p can promote angiogenic process through inhibiting epithelial protein lost in neoplasm (EPLIN) expression in HUVECs. In sum, our results have indicated that miR-93-5p promoted angiogenesis through down-regulating EPLIN and therefore represented a promising target for developing novel anti-angiogenic therapeutics.
L., L., L., Z., Y., Z., Q., Z., J., R., & X., Z. (2017). MiR-93-5p enhances growth and angiogenesis capacity of HUVECs by down-regulating EPLIN. Oncotarget, 8(63), 107033–107043. https://doi.org/10.18632/oncotarget.22300 LK - http://sfx.library.uu.nl/utrecht?sid=EMBASE&issn=19492553&id=doi:10.18632%2Foncotarget.22300&atitle=MiR-93-5p+enhances+growth+and+angiogenesis+capacity+of+HUVECs+by+down-regulating+EPLIN&stitle=Oncotarget&title=Oncotarget&volume=8&issue=63&spage=107033&epage=107043&aulast=Liang&aufirst=Liang&auinit=L.&aufull=Liang+L.&coden=&isbn=&pages=107033-107043&date=2017&auinit1=L&auinitm=