Mll5 is currently a member of the Mll family of SET domain histone methyltransferase proteins but studies have also showed that it could be part of the SET3 branch of proteins. Recently, constitutive knock out animal studies have shown that Mll5 is required for proper haematopoietic stem cell differentiation, and loss of Mll5 results in synthetic lethality for genome de-methylation. Mll5 deficient male mice are infertile and here we analyse the consequences of Mll5 deficiency for spermatogenesis.
Yap, D. B., Walker, D. C., Prentice, L. M., McKinney, S., Turashvili, G., Mooslehner-Allen, K., … Aparicio, S. (2011). Mll5 is required for normal spermatogenesis. PLoS ONE, 6(11). https://doi.org/10.1371/journal.pone.0027127