Mobilization of hematopoietic stem cells with lenograstim in healthy donors: Efficacy and safety analysis according to donor age

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Abstract

We reviewed and analyzed safety and efficacy data after mobilization with granulocyte colony-stimulating factor (G-CSF) according to healthy donor's (HDs) age as follows: <50years (HDs-1, n=161), aged 50 to 59years (HDs-2, n=62), and ≥60years or over (HDs-3, n=23). Two hundred forty-six HDs were evaluated, and their characteristics were well balanced among age groups: most were male, siblings, and HLA matched. According to age group, the median numbers of CD34+cells in the peripheral blood for HDs-1, HDs-2, and HDs-3 were, respectively, 44.5, 34.5, and 26 (HDs-1 versus HDs-2, P=.002; HDs-1 versus HDs-3, P=.036; HDs-2 versus HDs-3, P=n.s.) at day 4 and 65.5, 58, and 46 (HDs-1 versus HDs-2, P=.039; HDs-1 versus HDs-3, P=.002; HDs-2 versus HDs-3, P=n.s.) at day 5. With a median apheresis session of 1, the number of CD34+cells/kg recipient body weight collected was not significantly different (6.4 in HDs-1, 6.0 in HDs-2, and 5.7 in HDs-3, P=n.s.). Short- and long-term safety did not differ among age groups. Bone pain was reported as the most frequent short-term adverse event (76.5%). After a median follow-up of 7.8years, the observed rate of solid tumors, hematological malignancies, and cardiovascular and autoimmune events was similar to the expected incidence for these diseases in Western countries. These results show that G-CSF is effective in the mobilization of older HDs. Moreover, our data contribute to the growing body of evidence in support of the long-term safety of G-CSF for allogeneic donor stem cell mobilization also for elderly HDs.

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APA

Martino, M., Bonizzoni, E., Moscato, T., Recchia, A. G., Fedele, R., Gallo, G. A., … Morabito, F. (2015). Mobilization of hematopoietic stem cells with lenograstim in healthy donors: Efficacy and safety analysis according to donor age. Biology of Blood and Marrow Transplantation, 21(5), 881–888. https://doi.org/10.1016/j.bbmt.2015.01.021

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