An increased lifespan comes with an associated increase in disease incidence, and is the major risk factor for age-related diseases. To face this societal challenge search for new treatments has intensified requiring good preclinical models, whose complexity and accuracy is increasing. However, the influence of ageing is often overlooked. Furthermore, phenotypic assessment of ageing models is in need of standardisation to enable the accurate evaluation of pre-clinical intervention studies in line with clinical translation.
Bellantuono, I., & Potter, P. K. (2016, February 2). Modelling ageing and age-related disease. Drug Discovery Today: Disease Models. Elsevier Ltd. https://doi.org/10.1016/j.ddmod.2017.07.005