Modified glutamine catabolism in macrophages of Ucp2 knock-out mice

Citations of this article
Mendeley users who have this article in their library.


Uncoupling protein 2 (UCP2) belongs to a family of transporters of the mitochondrial inner membrane and is reported to uncouple respiration from ATP synthesis. Our observation that the amino acid glutamine specifically induces UCP2 protein expression prompted us to investigate metabolic consequences of a UCP2 knockdown (Ucp2-KO) when glutamine is offered as a substrate. We found that Ucp2-KO macrophages incubated in the presence of glutamine exhibit a lower ammonium release, a decreased respiratory rate, and an intracellular accumulation of aspartate. Therefore, we conclude that UCP2 expression is required for efficient oxidation of glutamine in macrophages. This role of UCP2 in glutamine metabolism appears independent from the uncoupling activity of UCP2. © 2007 Elsevier B.V. All rights reserved.




Nübel, T., Emre, Y., Rabier, D., Chadefaux, B., Ricquier, D., & Bouillaud, F. (2008). Modified glutamine catabolism in macrophages of Ucp2 knock-out mice. Biochimica et Biophysica Acta - Bioenergetics, 1777(1), 48–54.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free