Modulation of Kv4.3 current by accessory subunits

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Abstract

Kv4.3 encodes the pore-forming subunit of the cardiac transient outward potassium current (Ito). hKv4.3-encoded current does not fully replicate cardiac Ito, suggesting a functionally significant role for accessory subunits. KChIP2 associates with Kv4.3 and modifies hKv4.3-encoded currents but does not replicate native Ito. We examined the effect of several ancillary subunits expressed in the heart on hKv4.3-encoded currents. Remarkably, the ancillary subunits Kvβ3, minK, MiRP-1, the Na channel β1 and KChIP2 increased the density and modified the gating of hKv4.3 current. hKv4.3 promiscuously assembles with ancillary subunits in vitro, functionally modifying the encoded currents; however, the physiological significance is uncertain. © 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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Deschênes, I., & Tomaselli, G. F. (2002). Modulation of Kv4.3 current by accessory subunits. FEBS Letters, 528(1–3), 183–188. https://doi.org/10.1016/S0014-5793(02)03296-9

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