Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells

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Abstract

Legionella pneumophila is the causative agent of human Legionnaire's disease. During infection, the bacterium invades macrophages and lung epithelial cells, and replicates intracellularly. However, little is known about its interaction with T cells. We investigated the ability of L. pneumophila to infect and stimulate the production of interleukin-8 (IL-8) in T cells. The objective of this study was to assess whether L. pneumophila interferes with the immune system by interacting and infecting T cells.

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Takamatsu, R., Teruya, H., Takeshima, E., Ishikawa, C., Matsumoto, K., Mukaida, N., … Mori, N. (2010). Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells. BMC Microbiology, 10. https://doi.org/10.1186/1471-2180-10-1

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