Molecular Landscape of Non-Muscle Invasive Bladder Cancer

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Abstract

In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling. Tumors from female patients have a higher frequency of KDM6A mutations. In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling and increased risk of recurrence. Tumors from female patients have a higher frequency of KDM6A mutations.

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Meeks, J. J., & Lerner, S. P. (2017, November 13). Molecular Landscape of Non-Muscle Invasive Bladder Cancer. Cancer Cell. Cell Press. https://doi.org/10.1016/j.ccell.2017.08.015

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