Molecular mechanisms underlying bacterial persisters

292Citations
Citations of this article
772Readers
Mendeley users who have this article in their library.

Abstract

All bacteria form persisters, cells that are multidrug tolerant and therefore able to survive antibiotic treatment. Due to the low frequencies of persisters in growing bacterial cultures and the complex underlying molecular mechanisms, the phenomenon has been challenging to study. However, recent technological advances in microfluidics and reporter genes have improved this scenario. Here, we summarize recent progress in the field, revealing the ubiquitous bacterial stress alarmone ppGpp as an emerging central regulator of multidrug tolerance and persistence, both in stochastically and environmentally induced persistence. In several different organisms, toxin-antitoxin modules function as effectors of ppGpp-induced persistence. © 2014 Elsevier Inc.

Cite

CITATION STYLE

APA

Maisonneuve, E., & Gerdes, K. (2014, April 24). Molecular mechanisms underlying bacterial persisters. Cell. Cell Press. https://doi.org/10.1016/j.cell.2014.02.050

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free