Various members of the G protein-coupled receptor (GPCR) superfamily are known to modulate the release of insulin from pancreatic β cells. Rosengren and colleagues have recently provided convincing evidence for a role of increased expression of the α2A-adrenoceptor in β cells in the pathogenesis of type 2 diabetes. © 2010 Elsevier Inc. All rights reserved.
Wess, J. (2010, January 6). More Is Not Always Better: α2A-Adrenoceptor Expression in Type 2 Diabetes. Cell Metabolism. https://doi.org/10.1016/j.cmet.2009.12.002