Objective: To evaluate multimodal MRI of the spinal cord in predicting disease progression and one-year clinical status in amyotrophic lateral sclerosis (ALS) patients. Materials and Methods: After a first MRI (MRI 1), 29 ALS patients were clinically followed during 12 months; 14/29 patients underwent a second MRI (MRI2) at 1163 months. Cross-sectional area (CSA) that has been shown to be a marker of lower motor neuron degeneration was measured in cervical and upper thoracic spinal cord from T2-weighted images. Fractional anisotropy (FA), axial/radial/mean diffusivities (λ⊥, λ∥, MD) and magnetization transfer ratio (MTR) were measured within the lateral corticospinal tract in the cervical region. Imaging metrics were compared with clinical scales: Revised ALS Functional Rating Scale (ALSFRS-R) and manual muscle testing (MMT) score. Results: At MRI1, CSA correlated significantly (P<0.05) with MMT and arm ALSFRS-R scores. FA correlated significantly with leg ALFSRS-R scores. One year after MRI 1, CSA predicted (P<0.01) arm ALSFSR-R subscore and FA predicted (P<0.01) leg ALSFRS-R subscore. From MRI1 to MRI2, significant changes (P<0.01) were detected for CSA and MTR. CSA rate of change (i.e. atrophy) highly correlated (P<0.01) with arm ALSFRS-R and arm MMT subscores rate of change. Conclusion: Atrophy and DTI metrics predicted ALS disease progression. Cord atrophy was a better biomarker of disease progression than diffusion and MTR. Our study suggests that multimodal MRI could provide surrogate markers of ALS that may help monitoring the effect of disease-modifying drugs. © 2014 El Mendili et al.




M.-M., E. M., J., C.-A., M., P.-I., S., R., R., M.-K., V., M.-P., … P.-F., P. (2014). Multi-parametric spinal cord MRI as potential progression marker in amyotrophic lateral sclerosis. PLoS ONE, 9(4). https://doi.org/10.1371/journal.pone.0095516 LK  - http://sfx.library.uu.nl/utrecht?sid=EMBASE&issn=19326203&id=doi:10.1371%2Fjournal.pone.0095516&atitle=Multi-parametric+spinal+cord+MRI+as+potential+progression+marker+in+amyotrophic+lateral+sclerosis&stitle=PLoS+ONE&title=PLoS+ONE&volume=9&issue=4&spage=&epage=&aulast=El+Mendili&aufirst=Mohamed-Mounir&auinit=M.-M.&aufull=El+Mendili+M.-M.&coden=POLNC&isbn=&pages=-&date=2014&auinit1=M&auinitm=-M

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free