Multiple sclerosis: Interferon-beta induces CD123 +BDCA2 - dendritic cells that produce IL-6 and IL-10 and have no enhanced type I interferon production

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Abstract

Interferon-beta (IFN-β), an approved drug for multiple sclerosis (MS), acts on dendritic cells (DC) by suppressing IL-12p40 and increasing IL-10. This results in Th2-biased immune responses. The nature of IFN-β-modulated DC remains elusive. Previously, we observed that IFN-β dose dependently induces expression of CD123, i.e., a classical marker for plasmacytoid DC, on human blood monocyte-derived myeloid DC. Such IFN-β-modulated DCs produce predominantly IL-10 but are IL-12 deficient, with potent Th2 promotion. In the present study, we further characterize IFN-β-modulated DC by using recently identified blood DC antigens (BDCA), and investigate their ability to produce type I IFN in response to virus stimulation. We show that IFN-β induces development of CD123 + DC from human blood monocytes, which coexpress BDCA4 + but are negative for BDCA2 -, a specific marker for plasmacytoid DC. Such IFN-β-modulated DC can produce IL-6 and IL-10 but not IL-12p40, and have no enhanced IFN-α and IFN-β production. The findings indicate that IFN-β-modulated DCs represent a myeloid DC subset with diminished CD11c, BDCA-1 and CD1a expression. They may promote Th2 and B cell differentiation through IL-6 and IL-10 production, and suppression of IL-12p40, but they have no enhanced antiviral capacity. © 2004 Elsevier B.V. All rights reserved.

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Huang, Y. M., Adikari, S., Båve, U., Sanna, A., & Alm, G. (2005). Multiple sclerosis: Interferon-beta induces CD123 +BDCA2 - dendritic cells that produce IL-6 and IL-10 and have no enhanced type I interferon production. Journal of Neuroimmunology, 158(1–2), 204–212. https://doi.org/10.1016/j.jneuroim.2004.08.014

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