The murine telomerase catalytic subunit shares the PAb-240 mutant specific epitope of the p53 protein

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Abstract

Many tumorigenic p53 mutants gain a common antigenic epitope that is recognized by the PAb-240 antibody. Database search identified the presence of this epitope in several other proteins, including several antibodies and the catalytic subunit of mouse telomerase, mTERT. These antibodies may represent a part of the previously demonstrated anti-idiotypic network built around p53. In the present study we demonstrate that the PAb-240 antibody was able to inhibit telomerase activity in extracts from both mouse and human tumor cells. The recognition of mTERT by PAb-240 is demonstrated by Western blotting and by using blocking peptides derived from mTERT. The existence of a shared epitope between mutant p53 and telomerase may suggest that the two proteins contribute to malignant transformation through a common pathway. © 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

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Shats, I., Milyavsky, M., Erez, N., & Rotter, V. (2003). The murine telomerase catalytic subunit shares the PAb-240 mutant specific epitope of the p53 protein. FEBS Letters, 546(2–3), 321–324. https://doi.org/10.1016/S0014-5793(03)00607-0

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