The WNT4 gene plays an important role in female sex determination and differentiation. It also contributes to maintaining of the ovaries and the survival of follicles.
Chen, B., Suo, P., Wang, B., Wang, J., Yang, L., Zhou, S., … Cao, Y. (2011). Mutation analysis of the WNT4 gene in Han Chinese women with premature ovarian failure. Reproductive Biology and Endocrinology, 9. https://doi.org/10.1186/1477-7827-9-75