Angiogenesis is essential for normal and neoplastic tissue growth. In a recent issue of Nature, Komuro and colleagues (Sano et al., 2007) describe how p53 expression in hypertrophying heart muscle impairs HIF-1-mediated neovascularization and contributes to functional decompensation of pressure-overload cardiac hypertrophy. © 2007 Elsevier Inc. All rights reserved.
Dorn, G. W. (2007, May 9). Myocardial Angiogenesis: Its Absence Makes the Growing Heart Founder. Cell Metabolism. https://doi.org/10.1016/j.cmet.2007.04.003