Myocyte stress 1 plays an important role in cellular hypertrophy and protection against apoptosis

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Abstract

Myocyte stress 1 (MS1) is a recently described striated muscle actin-binding protein that is up-regulated in the early stages of pressure overload left ventricular hypertrophy. The aim of this study was to determine whether MS1 induces cellular hypertrophy and protects against apoptosis. Over-expressed MS1 co-localized with actin in H9c2 cells and altered expression of genes of the myocardin-related transcription factor (MRTF)/serum response factor (SRF) transcriptional pathways and in addition the apoptosis repressor with caspase recruitment domain (Nol3) gene. The size of cells over-expressing MS1 was significantly increased by 55% and over-expression of MS1 dramatically inhibited staurosporine-induced apoptosis by 89%. These findings suggest the involvement of MS1 in cellular hypertrophy and protection against apoptosis. © 2009.

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Koekemoer, A. L., Chong, N. W., Goodall, A. H., & Samani, N. J. (2009). Myocyte stress 1 plays an important role in cellular hypertrophy and protection against apoptosis. FEBS Letters, 583(17), 2964–2967. https://doi.org/10.1016/j.febslet.2009.08.011

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