Na,K-ATPase isozymes in colorectal cancer and liver metastases

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Abstract

© 2016 Baker Bechmann, Rotoli, Morales, Maeso, García, Ávila, Mobasheri and Martín-Vasallo. The goal of this study was to define Na,K-ATPase α and β subunit isoform expression and isozyme composition in colorectal cancer cells and liver metastases. The α1, α3, and β1 isoforms were the most highly expressed in tumor cells and metastases; in the plasma membrane of non-neoplastic cells and mainly in a cytoplasmic location in tumor cells. α1β1 and α3β1 isozymes found in tumor and metastatic cells exhibit the highest and lowest Na + affinity respectively and the highest K + affinity. Mesenchymal cell isozymes possess an intermediate Na + affinity and a low K + affinity. In cancer, these ions are likely to favor optimal conditions for the function of nuclear enzymes involved in mitosis, especially a high intra-nuclear K + concentration. A major and striking finding of this study was that in liver, metastasized CRC cells express the α3β1 isozyme. Thus, the α3β1 isozyme could potentially serve as a novel exploratory biomarker of CRC metastatic cells in liver.

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Bechmann, M. B., Rotoli, D., Morales, M., Maeso, M. del C., García, M. del P., Ávila, J., … Martín-Vasallo, P. (2016). Na,K-ATPase isozymes in colorectal cancer and liver metastases. Frontiers in Physiology, 7(JAN). https://doi.org/10.3389/fphys.2016.00009

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