Nasal potential difference: Best or average result for CFTR function as diagnostic criteria for cystic fibrosis?

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Abstract

Background: The current practice of averaging the nasal potential difference (NPD) results of right and left nostril measurements reduce inter-individual variability but may underestimate individual CFTR function. Methods: Best NPD response to Cl--free and isoproterenol perfusion (=largest δPD0Cl/Iso) from the right and left nostril was compared to the average result in 13 cystic fibrosis (CF), 78 query-CF patients and 22 healthy controls from 2 cohorts. Results: Despite moderate to good correlation (p<0.001) between right and left measured δPD0Cl/Iso, we observed large differences in some individuals. A comparison of average versus best δPD0Cl/Iso showed only moderate agreement (Giessen κ=0.538; Toronto κ=0.607). Averaging δPD0Cl/Iso showed a lower composite chloride response compared to best δPD0Cl/Iso and altered diagnostic NPD interpretation in 30 of 113 (27%) subjects. Conclusions: The current practice of averaging the NPD results of right and left nostril measurements leads to an underestimation of the individual CFTR function and should be reconsidered.

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APA

Keenan, K., Avolio, J., Rueckes-Nilges, C., Tullis, E., Gonska, T., & Naehrlich, L. (2015). Nasal potential difference: Best or average result for CFTR function as diagnostic criteria for cystic fibrosis? Journal of Cystic Fibrosis, 14(3), 310–316. https://doi.org/10.1016/j.jcf.2014.09.006

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