The natural history of medically treated temporal lobe epilepsy: What can an evidence-based approach tell us?

  • C.B. J
  • B. P
N/ACitations
Citations of this article
1Readers
Mendeley users who have this article in their library.

Abstract

We systematically reviewed the literature to describe the natural history of medically treated temporal lobe epilepsy (TLE). No population-based studies recruiting incident cases of TLE irrespective of age exist. Prospective, population-based studies were limited to those recruiting only childhood-onset TLE or those reporting TLE as a subgroup of cohorts of focal epilepsies. Few studies have been performed in the MRI era limiting information on natural history secondary to specific pathologies. Available data suggests that TLE is highly variable, with unpredictable transient remissions and low rates of seizure freedom (30 to 50%). Etiology and failure of first and second drug seem to be the most important predictors for treatment prognosis. The role of initial precipitating injuries remains speculative, as imaging information of related events is either missing or conflicting. Prospective cohorts of new-onset TLE with long-term followup using advanced MRI techniques, timely EEG recordings, and assessments of psychiatric comorbidities are needed. Copyright © 2012 Colin Bruce Josephson and Bernhard Pohlmann-Eden.

Cite

CITATION STYLE

APA

C.B., J., & B., P.-E. (2012). The natural history of medically treated temporal lobe epilepsy: What can an evidence-based approach tell us? Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed10&NEWS=N&AN=2012186978

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free