Epinephrine, first isolated around 1900, is the main sympathomimetic agent released by the adrenal gland. It plays an integral role in the treatment of several diseases in the emergency department. It effects on alpha and beta adrenergic receptors. In lower doses, it usually causes systemic and pulmonary vasodilatation, with some increase in heart rate and stroke volume. A high dose causes intense systemic vasoconstriction. Its metabolism is rapid and half-life is less than 5 minutes.
Nilden Tuygun, H. A. (2014). Nebulized Epinephrine Treatment in Pediatric Emergency Department. Pediatrics & Therapeutics, 04(03). https://doi.org/10.4172/2161-0665.1000210