Recent studies have shown that cytosolic Ca2+ signals, generated on one side of a nerve growth cone, can induce turning either towards or away from the side of the Ca2+ signal, depending on the global Ca2+ level. The results indicate that local Ca2+ signals may provide important directional cues for axon guidance.
Petersen, O. H., & Cancela, J. M. (2000, April 1). Nerve guidance: Attraction or repulsion by local Ca2+ signals. Current Biology. Current Biology Ltd. https://doi.org/10.1016/S0960-9822(00)00438-3