Neuroinflammation Screening in Immunotherapy Trials against Alzheimer's Disease

  • Andreasen N
  • Blennow K
  • Zetterberg H
N/ACitations
Citations of this article
8Readers
Mendeley users who have this article in their library.

Abstract

Due to side effects in the form of meningoencephalitis in the interrupted phase II AN1792 trial of active antiamyloid β (A β ) immunization against Alzheimer's disease (AD), there has been concern that anti-A β immunization may cause destructive neuroinflammation. Here, we report on two patients fulfilling clinical AD criteria who were diagnosed with Lyme neuroborreliosis during screening before inclusion in anti-A β immunotherapy trials. The two cases illustrate the necessity of careful biochemical screening for neuroinflammatory/neuroinfectious conditions before an AD diagnosis is made and before clinical AD patients are included in trials of therapy that could impact the immune system. Should the two cases have been included and deteriorated, additional investigations might have led to the erroneous conclusion that therapy-induced meningoencephalitis had occurred.

Cite

CITATION STYLE

APA

Andreasen, N., Blennow, K., & Zetterberg, H. (2010). Neuroinflammation Screening in Immunotherapy Trials against Alzheimer’s Disease. International Journal of Alzheimer’s Disease, 2010, 1–3. https://doi.org/10.4061/2010/638379

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free