Neuron-Astroglia Cell Fate Decision in the Adult Mouse Hippocampal Neurogenic Niche Is Cell-Intrinsically Controlled by COUP-TFI In Vivo

1Citations
Citations of this article
41Readers
Mendeley users who have this article in their library.

Abstract

The adult hippocampal dentate gyrus contains multipotent neural stem cells (NSCs) and neuronal committed progenitors. Bonzano et al. demonstrate that the nuclear receptor COUP-TFI cell-intrinsically drives NSCs/progenitors toward neurogenesis by repressing astrogliogenesis. Notably, COUP-TFI downregulation occurs in inflamed hippocampi, and its overexpression rescues the hippocampal neurogenesis-astrogliogenesis imbalance due to neuroinflammation.

Cite

CITATION STYLE

APA

Bonzano, S., Crisci, I., Podlesny-Drabiniok, A., Rolando, C., Krezel, W., Studer, M., & De Marchis, S. (2018). Neuron-Astroglia Cell Fate Decision in the Adult Mouse Hippocampal Neurogenic Niche Is Cell-Intrinsically Controlled by COUP-TFI In Vivo. Cell Reports, 24(2), 329–341. https://doi.org/10.1016/j.celrep.2018.06.044

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free