Neurons in the brain make many thousands of connections (synapses) with other neurons. In a Perspective, Thompson discusses a technical tour-de-force (Koester and Johnson) that reveals subtle differences in the characteristics of neurotransmitter release, which depend on the type of postsynaptic target cells with which the presynaptic cell connects.
Thompson, S. M. (2005). Neuroscience. Matching at the synapse. Science (New York, N.Y.), 308(5723), 800–801. https://doi.org/10.1126/science.1112623