New Cancer Stochastic Models Involving Both Hereditary and Nonhereditary Cancer Cases: A New Approach

  • Tan W
  • Zhou H
N/ACitations
Citations of this article
5Readers
Mendeley users who have this article in their library.

Abstract

To incorporate biologically observed epidemics into multistage models of carcinogenesis, in this paper we have developed new stochastic models for human cancers. We have further incorporated genetic segregation of cancer genes into these models to derive generalized mixture models for cancer incidence. Based on these models we have developed a generalized Bayesian approach to estimate the parameters and to predict cancer incidence via Gibbs sampling procedures. We have applied these models to fit and analyze the SEER data of human eye cancers from NCI/NIH. Our results indicate that the models not only provide a logical avenue to incorporate biological information but also fit the data much better than other models. These models would not only provide more insights into human cancers but also would provide useful guidance for its prevention and control and for prediction of future cancer cases.

Cite

CITATION STYLE

APA

Tan, W.-Y., & Zhou, H. (2013). New Cancer Stochastic Models Involving Both Hereditary and Nonhereditary Cancer Cases: A New Approach. ISRN Biomathematics, 2013, 1–19. https://doi.org/10.1155/2013/954912

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free