Regulatory T (Treg) cells are a group of cells that are heterogeneous in origin and in functional activity. Treg cells comprise a necessary balance to adaptive immune responses. As key regulators of self-tolerance, Treg cells have been involved in a series of pathologic processes and considered as therapeutic targets. Here, we summarize recent research regarding Treg cell origins and their functional classification, highlight the role of exosomes and non-coding RNA in modulating Treg cell homeostasis, and discuss the current understanding of resident Treg cells.
Li, P., Liu, C., Yu, Z., & Wu, M. (2016). New insights into regulatory T cells: Exosome- and non-coding RNA-mediated regulation of homeostasis and resident treg cells. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2016.00574