New lobane and cembrane diterpenes from two comorian soft corals

27Citations
Citations of this article
18Readers
Mendeley users who have this article in their library.

Abstract

Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fractionations provided a known antitumor promoter cembrane diterpenoid, (+)-sarcophytol-A (1), along with a new lobane diterpenoid, carbomethoxyfuscol (2), from Sarcophyton sp., and a new cembranoid, crassumolide E (3), from Lobophytum sp. The structures of compounds 1-3 were determined by spectroscopic analysis and by comparison of the spectral data with previously reported values. The cembranoid 3 was found to exhibit a moderate inhibitory effect on acetylcholinesterase. © 2010 by the authors; licensee Molecular Diversity Preservation International.

Cite

CITATION STYLE

APA

Bonnard, I., Jhaumeer-Laulloo, S. B., Bontemps, N., Banaigs, B., & Aknin, M. (2010). New lobane and cembrane diterpenes from two comorian soft corals. Marine Drugs, 8(2), 359–372. https://doi.org/10.3390/md8020359

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free